Normalization of Patient-Identified Plasma Biomarkers in SMNΔ7 Mice following Postnatal SMN Restoration

INTRODUCTION AND OBJECTIVE: Spinal muscular atrophy (SMA) is an autosomal recessive motor neuron disorder. SMA is caused by homozygous loss of the SMN1 gene and retention of the SMN2 gene resulting in reduced levels of full length SMN protein that are insufficient for motor neuron function. Various...

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Detalles Bibliográficos
Autores principales: Arnold, W. David, Duque, Sandra, Iyer, Chitra C., Zaworski, Phillip, McGovern, Vicki L., Taylor, Shannon J., von Herrmann, Katharine M., Kobayashi, Dione T., Chen, Karen S., Kolb, Stephen J., Paushkin, Sergey V., Burghes, Arthur H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132001/
https://www.ncbi.nlm.nih.gov/pubmed/27907033
http://dx.doi.org/10.1371/journal.pone.0167077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132001/
https://www.ncbi.nlm.nih.gov/pubmed/27907033
http://dx.doi.org/10.1371/journal.pone.0167077

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