Evaluation of the Effect of Tofacitinib on the Pharmacokinetics of Oral Contraceptive Steroids in Healthy Female Volunteers

Tofacitinib is an oral Janus kinase inhibitor. Tofacitinib metabolism is primarily mediated by cytochrome P450 3A4. This phase 1 randomized, open‐label, 2‐way crossover study (NCT01137708) evaluated the effect of tofacitinib 30 mg twice daily on the single‐dose pharmacokinetics of combination oral c...

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Detalles Bibliográficos
Autores principales: Menon, Sujatha, Riese, Richard, Wang, Ronnie, Alvey, Christine W., Shi, Haihong, Petit, Wendy, Krishnaswami, Sriram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132016/
https://www.ncbi.nlm.nih.gov/pubmed/27138968
http://dx.doi.org/10.1002/cpdd.270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132016/
https://www.ncbi.nlm.nih.gov/pubmed/27138968
http://dx.doi.org/10.1002/cpdd.270

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