High frequency of mitochondrial DNA mutations in HIV‐infected treatment‐experienced individuals

OBJECTIVES: We recently observed a decrease in deoxyribonucleotide (dNTP) pools in HIV‐infected individuals on antiretroviral therapy (ART). Alterations in dNTPs result in mutations in mitochondrial DNA (mtDNA) in cell culture and animal models. Therefore, we investigated whether ART is associated w...

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Detalles Bibliográficos
Autores principales: Li, M, Foli, Y, Liu, Z, Wang, G, Hu, Y, Lu, Q, Selvaraj, S, Lam, W, Paintsil, E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132110/
https://www.ncbi.nlm.nih.gov/pubmed/27328746
http://dx.doi.org/10.1111/hiv.12390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132110/
https://www.ncbi.nlm.nih.gov/pubmed/27328746
http://dx.doi.org/10.1111/hiv.12390

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