Structural Snapshots for Mechanism‐Based Inactivation of a Glycoside Hydrolase by Cyclopropyl Carbasugars

Glycoside hydrolases (GHs) have attracted considerable attention as targets for therapeutic agents, and thus mechanism‐based inhibitors are of great interest. We report the first structural analysis of a carbocyclic mechanism‐based GH inactivator, the results of which show that the two Michaelis com...

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Detalles Bibliográficos
Autores principales: Adamson, Christopher, Pengelly, Robert J., Shamsi Kazem Abadi, Saeideh, Chakladar, Saswati, Draper, Jason, Britton, Robert, Gloster, Tracey M., Bennet, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132143/
https://www.ncbi.nlm.nih.gov/pubmed/27783466
http://dx.doi.org/10.1002/anie.201607431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132143/
https://www.ncbi.nlm.nih.gov/pubmed/27783466
http://dx.doi.org/10.1002/anie.201607431

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