Mice Hemizygous for a Pathogenic Mitofusin-2 Allele Exhibit Hind Limb/Foot Gait Deficits and Phenotypic Perturbations in Nerve and Muscle

Charcot-Marie-Tooth disease type 2A (CMT2A), the most common axonal form of hereditary sensory motor neuropathy, is caused by mutations of mitofusin-2 (MFN2). Mitofusin-2 is a GTPase required for fusion of mitochondrial outer membranes, repair of damaged mitochondria, efficient mitochondrial energet...

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Detalles Bibliográficos
Autores principales: Bannerman, Peter, Burns, Travis, Xu, Jie, Miers, Laird, Pleasure, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132404/
https://www.ncbi.nlm.nih.gov/pubmed/27907123
http://dx.doi.org/10.1371/journal.pone.0167573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132404/
https://www.ncbi.nlm.nih.gov/pubmed/27907123
http://dx.doi.org/10.1371/journal.pone.0167573

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