MYOD1 (L122R) mutations are associated with spindle cell and sclerosing rhabdomyosarcomas with aggressive clinical outcomes

Recurrent mutations in the myogenic transcription factor MYOD1 and PIK3CA were initially described in a subset of embryonal rhabdomyosarcomas. Recently, two independent studies demonstrated presence of MYODI (L122R) mutations as the basis to re-classify a spindle cell rhabdomyosarcoma, along with a...

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Detalles Bibliográficos
Autores principales: Rekhi, Bharat, Upadhyay, Pawan, Ramteke, Manoj P, Dutt, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133269/
https://www.ncbi.nlm.nih.gov/pubmed/27562493
http://dx.doi.org/10.1038/modpathol.2016.144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133269/
https://www.ncbi.nlm.nih.gov/pubmed/27562493
http://dx.doi.org/10.1038/modpathol.2016.144

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