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Intracerebroventricular Catalase Reduces Hepatic Insulin Sensitivity and Increases Responses to Hypoglycemia in Rats

Specialized metabolic sensors in the hypothalamus regulate blood glucose levels by influencing hepatic glucose output and hypoglycemic counterregulatory responses. Hypothalamic reactive oxygen species (ROS) may act as a metabolic signal-mediating responses to changes in glucose, other substrates and...

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Detalles Bibliográficos
Autores principales: Pauliina Markkula, S., Lyons, David, Yueh, Chen-Yu, Riches, Christine, Hurst, Paul, Fielding, Barbara, Heisler, Lora K., Evans, Mark L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133351/
https://www.ncbi.nlm.nih.gov/pubmed/27740870
http://dx.doi.org/10.1210/en.2015-2054