Tumor hypoxia causes DNA hypermethylation by reducing TET activity

Hypermethylation of tumor suppressor gene (TSG) promoters confers growth advantages to cancer cells, but how these changes arise is poorly understood. Here, we report that tumor hypoxia reduces the activity of oxygen-dependent TET enzymes, which catalyze DNA de-methylation through 5-methylcytosine o...

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Detalles Bibliográficos
Autores principales: Thienpont, Bernard, Steinbacher, Jessica, Zhao, Hui, D’Anna, Flora, Kuchnio, Anna, Ploumakis, Athanasios, Ghesquière, Bart, Van Dyck, Laurien, Boeckx, Bram, Schoonjans, Luc, Hermans, Els, Amant, Frederic, Kristensen, Vessela N., Peng Koh, Kian, Mazzone, Massimiliano, Coleman, Mathew, Carell, Thomas, Carmeliet, Peter, Lambrechts, Diether
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133388/
https://www.ncbi.nlm.nih.gov/pubmed/27533040
http://dx.doi.org/10.1038/nature19081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133388/
https://www.ncbi.nlm.nih.gov/pubmed/27533040
http://dx.doi.org/10.1038/nature19081

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