Cargando…

Efficacy and Safety of High-Dose Ivermectin for Reducing Malaria Transmission (IVERMAL): Protocol for a Double-Blind, Randomized, Placebo-Controlled, Dose-Finding Trial in Western Kenya

BACKGROUND: Innovative approaches are needed to complement existing tools for malaria elimination. Ivermectin is a broad spectrum antiparasitic endectocide clinically used for onchocerciasis and lymphatic filariasis control at single doses of 150 to 200 mcg/kg. It also shortens the lifespan of mosqu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Smit, Menno R, Ochomo, Eric, Aljayyoussi, Ghaith, Kwambai, Titus, Abong'o, Bernard, Bayoh, Nabie, Gimnig, John, Samuels, Aaron, Desai, Meghna, Phillips-Howard, Penelope A, Kariuki, Simon, Wang, Duolao, Ward, Steve, ter Kuile, Feiko O
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	JMIR Publications 2016
Materias:	Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133431/ https://www.ncbi.nlm.nih.gov/pubmed/27856406 http://dx.doi.org/10.2196/resprot.6617

Ejemplares similares

Pharmacokinetics‐Pharmacodynamics of High‐Dose Ivermectin with Dihydroartemisinin‐Piperaquine on Mosquitocidal Activity and QT‐Prolongation (IVERMAL)
por: Smit, Menno R., et al.
Publicado: (2018)

Human Direct Skin Feeding Versus Membrane Feeding to Assess the Mosquitocidal Efficacy of High-Dose Ivermectin (IVERMAL Trial)
por: Smit, Menno R, et al.
Publicado: (2019)

Evaluation of community-based vector surveillance system for routine entomological monitoring under low malaria vector densities and high bed net coverage in western Kenya
por: Abong’o, Bernard, et al.
Publicado: (2023)

Screening eaves of houses reduces indoor mosquito density in rural, western Kenya
por: Abong’o, Bernard, et al.
Publicado: (2022)

Natural sugar feeding rates of Anopheles mosquitoes collected by different methods in western Kenya
por: Omondi, Seline, et al.
Publicado: (2022)

Host Decoy Trap (HDT) with cattle odour is highly effective for collection of exophagic malaria vectors
por: Abong’o, Bernard, et al.
Publicado: (2018)

Post-Discharge Risk of Mortality in Children under 5 Years of Age in Western Kenya: A Retrospective Cohort Study
por: Kwambai, Titus K., et al.
Publicado: (2023)

Malaria chemoprevention with monthly dihydroartemisinin-piperaquine for the post-discharge management of severe anaemia in children aged less than 5 years in Uganda and Kenya: study protocol for a multi-centre, two-arm, randomised, placebo-controlled, superiority trial
por: Kwambai, Titus K., et al.
Publicado: (2018)

The efficacy of long-lasting nets with declining physical integrity may be compromised in areas with high levels of pyrethroid resistance
por: Ochomo, Eric O, et al.
Publicado: (2013)

Temporal trends in molecular markers of drug resistance in Plasmodium falciparum in human blood and profiles of corresponding resistant markers in mosquito oocysts in Asembo, western Kenya
por: Zhou, Zhiyong, et al.
Publicado: (2022)

Impact of indoor residual spraying with pirimiphos-methyl (Actellic 300CS) on entomological indicators of transmission and malaria case burden in Migori County, western Kenya
por: Abong’o, Bernard, et al.
Publicado: (2020)

The Effect of Indoor Residual Spraying on the Prevalence of Malaria Parasite Infection, Clinical Malaria and Anemia in an Area of Perennial Transmission and Moderate Coverage of Insecticide Treated Nets in Western Kenya
por: Gimnig, John E., et al.
Publicado: (2016)

Efficacy of extended release formulations of Natular™ (spinosad) against larvae and adults of Anopheles mosquitoes in western Kenya
por: Gimnig, John E., et al.
Publicado: (2020)

Evaluation of the protective efficacy of a spatial repellent to reduce malaria incidence in children in western Kenya compared to placebo: study protocol for a cluster-randomized double-blinded control trial (the AEGIS program)
por: Ochomo, Eric O., et al.
Publicado: (2022)

Perspectives of men on antenatal and delivery care service utilisation in rural western Kenya: a qualitative study
por: Kwambai, Titus K, et al.
Publicado: (2013)

Socioeconomic health inequality in malaria indicators in rural western Kenya: evidence from a household malaria survey on burden and care-seeking behaviour
por: Were, Vincent, et al.
Publicado: (2018)

Trends in malaria prevalence and health related socioeconomic inequality in rural western Kenya: results from repeated household malaria cross-sectional surveys from 2006 to 2013
por: Were, Vincent, et al.
Publicado: (2019)

Provider knowledge of treatment policy and dosing regimen with artemether-lumefantrine and quinine in malaria-endemic areas of western Kenya
por: Watsierah, Carren A, et al.
Publicado: (2012)

PRObiotics and SYNbiotics to improve gut health and growth in infants in western Kenya (PROSYNK Trial): study protocol for a 4-arm, open-label, randomised, controlled trial
por: Otiti, Mary Iwaret, et al.
Publicado: (2022)

Community-based intermittent mass testing and treatment for malaria in an area of high transmission intensity, western Kenya: development of study site infrastructure and lessons learned
por: Odero, Norbert Awino, et al.
Publicado: (2019)

Intracellular PD Modelling (PD(i)) for the Prediction of Clinical Activity of Increased Rifampicin Dosing
por: Aljayyoussi, Ghaith, et al.
Publicado: (2019)

Presence of the knockdown resistance mutation, Vgsc-1014F in Anopheles gambiae and An. arabiensis in western Kenya
por: Ochomo, Eric, et al.
Publicado: (2015)

Infant and child mortality in relation to malaria transmission in KEMRI/CDC HDSS, Western Kenya: validation of verbal autopsy
por: Amek, Nyaguara O., et al.
Publicado: (2018)

Quantifying the intensity of permethrin insecticide resistance in Anopheles mosquitoes in western Kenya
por: Omondi, Seline, et al.
Publicado: (2017)

Standard Dose Ivermectin for COVID-19
por: Buonfrate, Dora, et al.
Publicado: (2021)

A comparison of the attractiveness of flowering plant blossoms versus attractive targeted sugar baits (ATSBs) in western Kenya
por: Yalla, Nick, et al.
Publicado: (2023)

Community-based intermittent mass testing and treatment for malaria in an area of high transmission intensity, western Kenya: study design and methodology for a cluster randomized controlled trial
por: Samuels, Aaron M., et al.
Publicado: (2017)

Safety, tolerability, and efficacy of repeated doses of dihydroartemisinin-piperaquine for prevention and treatment of malaria: a systematic review and meta-analysis
por: Gutman, Julie, et al.
Publicado: (2017)

Decline in frequency of the 2La chromosomal inversion in Anopheles gambiae (s.s.) in Western Kenya: correlation with increase in ownership of insecticide-treated bed nets
por: Matoke-Muhia, Damaris, et al.
Publicado: (2016)

The Approved Dose of Ivermectin Alone is not the Ideal Dose for the Treatment of COVID‐19
por: Schmith, Virginia D., et al.
Publicado: (2020)

Spatial and temporal dynamics of malaria transmission in rural Western Kenya
por: Amek, Nyaguara, et al.
Publicado: (2012)

Late morning biting behaviour of Anopheles funestus is a risk factor for transmission in schools in Siaya, western Kenya
por: Omondi, Seline, et al.
Publicado: (2023)

Pharmacovigilance for single low-dose primaquine: a practical approach
por: Poirot, Eugenie, et al.
Publicado: (2014)

Economic evaluation of postdischarge malaria chemoprevention in preschool children treated for severe anaemia in Malawi, Kenya, and Uganda: A cost-effectiveness analysis
por: Kühl, Melf-Jakob, et al.
Publicado: (2022)

Comparison of four outdoor mosquito trapping methods as potential replacements for human landing catches in western Kenya
por: Abong’o, Bernard, et al.
Publicado: (2021)

Standardizing operational vector sampling techniques for measuring malaria transmission intensity: evaluation of six mosquito collection methods in western Kenya
por: Wong, Jacklyn, et al.
Publicado: (2013)

Spatial and temporal variation in the kdr allele L1014S in Anopheles gambiae s.s. and phenotypic variability in susceptibility to insecticides in Western Kenya
por: Mathias, Derrick K, et al.
Publicado: (2011)

Persistently high estimates of late night, indoor exposure to malaria vectors despite high coverage of insecticide treated nets
por: Nabie Bayoh, M, et al.
Publicado: (2014)

The harms of police frisking in times of a pandemic
por: Aljayyoussi, Ghaith
Publicado: (2020)

Establishment of the Ivermectin Research for Malaria Elimination Network: updating the research agenda
por: Chaccour, Carlos J, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_b1itlgo9g3jnrltra2i0rq59gs