Type I error rates of rare single nucleotide variants are inflated in tests of association with non–normally distributed traits using simple linear regression methods

In this study, the effects of (a) the minor allele frequency of the single nucleotide variant (SNV), (b) the degree of departure from normality of the trait, and (c) the position of the SNVs on type I error rates were investigated in the Genetic Analysis Workshop (GAW) 19 whole exome sequence data....

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Detalles Bibliográficos
Autores principales: Schwantes-An, Tae-Hwi, Sung, Heejong, Sabourin, Jeremy A., Justice, Cristina M., Sorant, Alexa J. M., Wilson, Alexander F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133479/
https://www.ncbi.nlm.nih.gov/pubmed/27980666
http://dx.doi.org/10.1186/s12919-016-0060-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133479/
https://www.ncbi.nlm.nih.gov/pubmed/27980666
http://dx.doi.org/10.1186/s12919-016-0060-7

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