Finding potential cis-regulatory loci using allele-specific chromatin accessibility as weights in a kernel-based variance component test

We present a novel approach to detect potential cis-acting regulatory loci that combines the functional potential, an empirical DNase-seq based estimate of the allele-specificity of DNase-I hypersensitivity sites, with kernel-based variance component association analyses against expression phenotype...

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Detalles Bibliográficos
Autores principales: Peralta, Juan Manuel, Almeida, Marcio, Abraham, Lawrence J., Moses, Eric, Blangero, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133489/
https://www.ncbi.nlm.nih.gov/pubmed/27980619
http://dx.doi.org/10.1186/s12919-016-0013-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133489/
https://www.ncbi.nlm.nih.gov/pubmed/27980619
http://dx.doi.org/10.1186/s12919-016-0013-1

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