5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients

Glioblastomas exhibit widespread molecular alterations including a highly distorted epigenome. Here, we resolve genome-wide 5-methylcytosine and 5-hydroxymethylcytosine in glioblastoma through parallel processing of DNA with bisulfite and oxidative bisulfite treatments. We apply a statistical algori...

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Detalles Bibliográficos
Autores principales: Johnson, Kevin C., Houseman, E. Andres, King, Jessica E., von Herrmann, Katharine M., Fadul, Camilo E., Christensen, Brock C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133638/
https://www.ncbi.nlm.nih.gov/pubmed/27886174
http://dx.doi.org/10.1038/ncomms13177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133638/
https://www.ncbi.nlm.nih.gov/pubmed/27886174
http://dx.doi.org/10.1038/ncomms13177

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