Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

Despite widespread use of statins to reduce low-density lipoprotein cholesterol (LDL-C) and associated atherosclerotic cardiovascular risk, many patients do not achieve sufficient LDL-C lowering due to muscle-related side effects, indicating novel treatment strategies are required. Bempedoic acid (E...

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Detalles Bibliográficos
Autores principales: Pinkosky, Stephen L., Newton, Roger S., Day, Emily A., Ford, Rebecca J., Lhotak, Sarka, Austin, Richard C., Birch, Carolyn M., Smith, Brennan K., Filippov, Sergey, Groot, Pieter H.E., Steinberg, Gregory R., Lalwani, Narendra D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133702/
https://www.ncbi.nlm.nih.gov/pubmed/27892461
http://dx.doi.org/10.1038/ncomms13457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133702/
https://www.ncbi.nlm.nih.gov/pubmed/27892461
http://dx.doi.org/10.1038/ncomms13457

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