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Antibody responses to de novo identified citrullinated fibrinogen peptides in rheumatoid arthritis and visualization of the corresponding B cells

BACKGROUND: Antibodies against citrullinated proteins (ACPA) are common in patients with rheumatoid arthritis (RA). ACPA can appear before disease onset and target many self-antigens. Citrullinated fibrin/fibrinogen represents a classical ACPA target antigen, and mass spectrometry of RA synovial flu...

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Detalles Bibliográficos
Autores principales: Joshua, Vijay, Schobers, Loes, Titcombe, Philip J., Israelsson, Lena, Rönnelid, Johan, Hansson, Monika, Catrina, Anca I., Pruijn, Ger J. M., Malmström, Vivianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133744/
https://www.ncbi.nlm.nih.gov/pubmed/27906052
http://dx.doi.org/10.1186/s13075-016-1181-0