Effect of Post-Translational Amidation on Islet Amyloid Polypeptide Conformational Ensemble: Implications for Its Aggregation Early Steps

The human islet amyloid polypeptide (hIAPP) is an intrinsically disordered protein that can self-assemble into fibrillar aggregates that play a key role in the pathogenesis of the type II diabetes mellitus. hIAPP can transiently adopt [Formula: see text]-helix and [Formula: see text]-strand conforma...

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Detalles Bibliográficos
Autores principales: Tran, Linh, Ha-Duong, Tâp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133895/
https://www.ncbi.nlm.nih.gov/pubmed/27854243
http://dx.doi.org/10.3390/ijms17111896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133895/
https://www.ncbi.nlm.nih.gov/pubmed/27854243
http://dx.doi.org/10.3390/ijms17111896

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