Inactivation of Sirt1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-κB

Sirtuin 1 (Sirt1) is a deacetylase that regulates many cellular processes in the liver, and so far its role in endotoxemic liver injury is elusive. So we conditionally inactivate Sirt1 in murine hepatocytes to determine its role in d-galactosamine (GalN)/lipopolysaccharide (LPS)-induced liver damage...

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Detalles Bibliográficos
Autores principales: Cui, Xiaolan, Chen, Qian, Dong, Zhen, Xu, Longmei, Lu, Tianfei, Li, Dawei, Zhang, Jiangjun, Zhang, Ming, Xia, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133964/
https://www.ncbi.nlm.nih.gov/pubmed/27711079
http://dx.doi.org/10.1038/cddis.2016.270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133964/
https://www.ncbi.nlm.nih.gov/pubmed/27711079
http://dx.doi.org/10.1038/cddis.2016.270

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