1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes

Impaired apoptosis of fibroblast-like synoviocytes (FLSs) causes synovial hyperplasia, facilitating destruction of cartilage and bone in rheumatoid arthritis (RA). Tumor necrosis factor (TNF)-α, a dominant inflammatory mediator in RA pathogenesis, promotes progression of RA symptoms. Prevalence of 1...

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Detalles Bibliográficos
Autores principales: Gu, Xin, Gu, Bingjie, Lv, Xianhui, Yu, Zhenzhen, Wang, Rong, Zhou, Xiaoli, Qiao, Wanxin, Mao, Zhiyuan, Zuo, Guoping, Li, Qing, Miao, Dengshun, Jin, Jianliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133971/
https://www.ncbi.nlm.nih.gov/pubmed/27763638
http://dx.doi.org/10.1038/cddis.2016.300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133971/
https://www.ncbi.nlm.nih.gov/pubmed/27763638
http://dx.doi.org/10.1038/cddis.2016.300

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