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1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes

Impaired apoptosis of fibroblast-like synoviocytes (FLSs) causes synovial hyperplasia, facilitating destruction of cartilage and bone in rheumatoid arthritis (RA). Tumor necrosis factor (TNF)-α, a dominant inflammatory mediator in RA pathogenesis, promotes progression of RA symptoms. Prevalence of 1...

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Detalles Bibliográficos
Autores principales:	Gu, Xin, Gu, Bingjie, Lv, Xianhui, Yu, Zhenzhen, Wang, Rong, Zhou, Xiaoli, Qiao, Wanxin, Mao, Zhiyuan, Zuo, Guoping, Li, Qing, Miao, Dengshun, Jin, Jianliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133971/ https://www.ncbi.nlm.nih.gov/pubmed/27763638 http://dx.doi.org/10.1038/cddis.2016.300

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