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Hypoxia-induced expression of cellular prion protein improves the therapeutic potential of mesenchymal stem cells

Mesenchymal stem cells (MSCs) are ‘adult' multipotent cells that promote regeneration of injured tissues in vivo. However, differences in oxygenation levels between normoxic culture conditions (21% oxygen) and both the MSC niche (2–8% oxygen) and ischemic injury-induced oxidative stress conditi...

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Detalles Bibliográficos
Autores principales: Han, Yong-Seok, Lee, Jun Hee, Yoon, Yeo Min, Yun, Chul Won, Noh, Hyunjin, Lee, Sang Hun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133977/
https://www.ncbi.nlm.nih.gov/pubmed/27711081
http://dx.doi.org/10.1038/cddis.2016.310