Cargando…

Hypoxia-induced expression of cellular prion protein improves the therapeutic potential of mesenchymal stem cells

Mesenchymal stem cells (MSCs) are ‘adult' multipotent cells that promote regeneration of injured tissues in vivo. However, differences in oxygenation levels between normoxic culture conditions (21% oxygen) and both the MSC niche (2–8% oxygen) and ischemic injury-induced oxidative stress conditi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Yong-Seok, Lee, Jun Hee, Yoon, Yeo Min, Yun, Chul Won, Noh, Hyunjin, Lee, Sang Hun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133977/ https://www.ncbi.nlm.nih.gov/pubmed/27711081 http://dx.doi.org/10.1038/cddis.2016.310

Ejemplares similares

Role of hypoxia-mediated cellular prion protein functional change in stem cells and potential application in angiogenesis
por: Yun, Seung Pil, et al.
Publicado: (2017)

Tauroursodeoxycholic acid reduces ER stress by regulating of Akt-dependent cellular prion protein
por: Yoon, Yeo Min, et al.
Publicado: (2016)

TUDCA-treated chronic kidney disease-derived hMSCs improve therapeutic efficacy in ischemic disease via PrP(C)
por: Yoon, Yeo Min, et al.
Publicado: (2019)

Co-Administration of Melatonin Effectively Enhances the Therapeutic Effects of Pioglitazone on Mesenchymal Stem Cells Undergoing Indoxyl Sulfate-Induced Senescence through Modulation of Cellular Prion Protein Expression
por: Han, Yong Seok, et al.
Publicado: (2018)

Melatonin protects mesenchymal stem cells from autophagy‐mediated death under ischaemic ER‐stress conditions by increasing prion protein expression
por: Lee, Jun Hee, et al.
Publicado: (2018)

Melatonin suppresses senescence‐derived mitochondrial dysfunction in mesenchymal stem cells via the HSPA1L–mitophagy pathway
por: Lee, Jun Hee, et al.
Publicado: (2020)

Pioglitazone Improves the Function of Human Mesenchymal Stem Cells in Chronic Kidney Disease Patients
por: Yoon, Yeo Min, et al.
Publicado: (2019)

Pioglitazone Protects Mesenchymal Stem Cells against P-Cresol-Induced Mitochondrial Dysfunction via Up-Regulation of PINK-1
por: Yoon, Yeo Min, et al.
Publicado: (2018)

Cellular Prion Protein Enhances Drug Resistance of Colorectal Cancer Cells via Regulation of a Survival Signal Pathway
por: Lee, Jun Hee, et al.
Publicado: (2018)

Tauroursodeoxycholic Acid Protects against the Effects of P-Cresol-Induced Reactive Oxygen Species via the Expression of Cellular Prion Protein
por: Yun, Seung Pil, et al.
Publicado: (2018)

The Cellular Prion Protein: A Promising Therapeutic Target for Cancer
por: Go, Gyeongyun, et al.
Publicado: (2020)

Melatonin Protects Human Renal Proximal Tubule Epithelial Cells Against High Glucose-Mediated Fibrosis via the Cellular Prion Protein-TGF-β-Smad Signaling Axis
por: Han, Yong-Seok, et al.
Publicado: (2020)

Fucoidan Rescues p-Cresol-Induced Cellular Senescence in Mesenchymal Stem Cells via FAK-Akt-TWIST Axis
por: Lee, Jun Hee, et al.
Publicado: (2018)

Antioxidant effects of Cirsium setidens extract on oxidative stress in human mesenchymal stem cells
por: Lee, Jun Hee, et al.
Publicado: (2016)

Enhancement of Functionality and Therapeutic Efficacy of Cell-Based Therapy Using Mesenchymal Stem Cells for Cardiovascular Disease
por: Yun, Chul Won, et al.
Publicado: (2019)

Prion Protein of Extracellular Vesicle Regulates the Progression of Colorectal Cancer
por: Yun, Chul-Won, et al.
Publicado: (2021)

Potential and Therapeutic Efficacy of Cell-based Therapy Using Mesenchymal Stem Cells for Acute/chronic Kidney Disease
por: Yun, Chul Won, et al.
Publicado: (2019)

Exosomes isolated from melatonin-stimulated mesenchymal stem cells improve kidney function by regulating inflammation and fibrosis in a chronic kidney disease mouse model
por: Yea, Ji-Hye, et al.
Publicado: (2021)

Pretreatment with Lycopene Attenuates Oxidative Stress-Induced Apoptosis in Human Mesenchymal Stem Cells
por: Kim, Ji Yong, et al.
Publicado: (2015)

Induction of cellular prion protein (PrPc) under hypoxia inhibits apoptosis caused by TRAIL treatment
por: Park, Jin-Young, et al.
Publicado: (2015)

Correction: Yun et al. Prion Protein of Extracellular Vesicle Regulates the Progression of Colorectal Cancer. Cancers 2021, 13, 2144
por: Yun, Chul-Won, et al.
Publicado: (2021)

CD11c(+) Cells Partially Mediate the Renoprotective Effect Induced by Bone Marrow-Derived Mesenchymal Stem Cells
por: Kim, Myung-Gyu, et al.
Publicado: (2013)

Hypoxic Preconditioning Promotes the Bioactivities of Mesenchymal Stem Cells via the HIF-1α-GRP78-Akt Axis
por: Lee, Jun Hee, et al.
Publicado: (2017)

TUDCA-Treated Mesenchymal Stem Cells Protect against ER Stress in the Hippocampus of a Murine Chronic Kidney Disease Model
por: Lee, Jun Hee, et al.
Publicado: (2019)

Cripto Enhances Proliferation and Survival of Mesenchymal Stem Cells by Up-Regulating JAK2/STAT3 Pathway in a GRP78-Dependent Manner
por: Yun, SeungPil, et al.
Publicado: (2018)

Melatonin-Induced PGC-1α Improves Angiogenic Potential of Mesenchymal Stem Cells in Hindlimb Ischemia
por: Lee, Jun Hee, et al.
Publicado: (2020)

Regulation of RhoA activity by the cellular prion protein
por: Kim, Hee-Jun, et al.
Publicado: (2017)

Long-Duration Three-Dimensional Spheroid Culture Promotes Angiogenic Activities of Adipose-Derived Mesenchymal Stem Cells
por: Lee, Jun Hee, et al.
Publicado: (2016)

Hypoxia accelerates vascular repair of endothelial colony-forming cells on ischemic injury via STAT3-BCL3 axis
por: Lee, Sang Hun, et al.
Publicado: (2015)

Melatonin Enhances Mitophagy by Upregulating Expression of Heat Shock 70 kDa Protein 1L in Human Mesenchymal Stem Cells under Oxidative Stress
por: Yoon, Yeo Min, et al.
Publicado: (2019)

Melatonin Rescues Mesenchymal Stem Cells from Senescence Induced by the Uremic Toxin p-Cresol via Inhibiting mTOR-Dependent Autophagy
por: Yun, Seung Pil, et al.
Publicado: (2018)

Erratum to "Cripto Enhances Proliferation and Survival of Mesenchymal Stem Cells by Up-Regulating JAK2/STAT3 Pathway in a GRP78-Dependent Manner" [Biomol. Ther. 26 (2018) 464-473]
por: Yun, SeungPil, et al.
Publicado: (2021)

BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells
por: Lee, Hyun Jik, et al.
Publicado: (2017)

Erratum to "Melatonin-Induced PGC-1α Improves Angiogenic Potential of Mesenchymal Stem Cells in Hindlimb Ischemia" [Biomol. Ther. 28 (2020) 240-249]
por: Lee, Jun Hee, et al.
Publicado: (2021)

Mesenchymal Stem Cells and Exosomes: A Novel Therapeutic Approach for Corneal Diseases
por: Bhujel, Basanta, et al.
Publicado: (2023)

Metformin inhibits chronic kidney disease‐induced DNA damage and senescence of mesenchymal stem cells
por: Kim, Hyoungnae, et al.
Publicado: (2021)

The Role of Cellular Prion Protein in Promoting Stemness and Differentiation in Cancer
por: Ryskalin, Larisa, et al.
Publicado: (2021)

Implantation of Hypoxia-Induced Mesenchymal Stem Cell Advances Therapeutic Angiogenesis
por: Yusoff, Farina Mohamad, et al.
Publicado: (2022)

Survival of hypoxic human mesenchymal stem cells is enhanced by a positive feedback loop involving miR-210 and hypoxia-inducible factor 1
por: Chang, Woochul, et al.
Publicado: (2013)

Therapeutic Effects of Human Mesenchymal Stem Cells in a Mouse Model of Cerebellar Ataxia with Neuroinflammation
por: Nam, Youngpyo, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_b9lrpf42sn02fndlgoodnatrjj