Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

Intervertebral disc degeneration (IDD) is a complicated process that involves both cellular apoptosis and senescence. Metformin has been reported to stimulate autophagy, whereas autophagy is shown to protect against apoptosis and senescence. Therefore, we hypothesize that metformin may have therapeu...

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Detalles Bibliográficos
Autores principales: Chen, Deheng, Xia, Dongdong, Pan, Zongyou, Xu, Daoliang, Zhou, Yifei, Wu, Yaosen, Cai, Ningyu, Tang, Qian, Wang, Chenggui, Yan, Meijun, Zhang, Jing Jie, Zhou, Kailiang, Wang, Quan, Feng, Yongzeng, Wang, Xiangyang, Xu, Huazi, Zhang, Xiaolei, Tian, Naifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133996/
https://www.ncbi.nlm.nih.gov/pubmed/27787519
http://dx.doi.org/10.1038/cddis.2016.334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133996/
https://www.ncbi.nlm.nih.gov/pubmed/27787519
http://dx.doi.org/10.1038/cddis.2016.334

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