Nuclear bodies reorganize during myogenesis in vitro and are differentially disrupted by expression of FSHD-associated DUX4

BACKGROUND: Nuclear bodies, such as nucleoli, PML bodies, and SC35 speckles, are dynamic sub-nuclear structures that regulate multiple genetic and epigenetic processes. Additional regulation is provided by RNA/DNA handling proteins, notably TDP-43 and FUS, which have been linked to ALS pathology. Pr...

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Detalles Bibliográficos
Autores principales: Homma, Sachiko, Beermann, Mary Lou, Yu, Bryant, Boyce, Frederick M., Miller, Jeffrey Boone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134237/
https://www.ncbi.nlm.nih.gov/pubmed/27906075
http://dx.doi.org/10.1186/s13395-016-0113-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134237/
https://www.ncbi.nlm.nih.gov/pubmed/27906075
http://dx.doi.org/10.1186/s13395-016-0113-7

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