Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms

Leishmania infantum is an etiological agent of the life-threatening visceral form of leishmaniasis. Liposomal amphotericin B (AmB) followed by a short administration of miltefosine (MF) is a drug combination effective for treating visceral leishmaniasis in endemic regions of India. Resistance to MF...

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Detalles Bibliográficos
Autores principales: Fernandez-Prada, Christopher, Vincent, Isabel M., Brotherton, Marie-Christine, Roberts, Mathew, Roy, Gaétan, Rivas, Luis, Leprohon, Philippe, Smith, Terry K., Ouellette, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135041/
https://www.ncbi.nlm.nih.gov/pubmed/27911896
http://dx.doi.org/10.1371/journal.pntd.0005171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135041/
https://www.ncbi.nlm.nih.gov/pubmed/27911896
http://dx.doi.org/10.1371/journal.pntd.0005171

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