Isoform-Specific Effects of Wild-Type Ras Genes on Carcinogen-Induced Lung Tumorigenesis in Mice

The gene KRAS is commonly mutated in lung cancer to encode a constitutively active and oncogenic protein that is well established to initiate and maintain lung tumorigenesis. However, the remaining wild-type KRAS protein, or the other family members HRAS and NRAS, can still be activated in the prese...

Descripción completa

Detalles Bibliográficos
Autores principales: Weyandt, Jamie D., Carney, John M., Pavlisko, Elizabeth N., Xu, MengMeng, Counter, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135096/
https://www.ncbi.nlm.nih.gov/pubmed/27911940
http://dx.doi.org/10.1371/journal.pone.0167205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135096/
https://www.ncbi.nlm.nih.gov/pubmed/27911940
http://dx.doi.org/10.1371/journal.pone.0167205

Ejemplares similares