Cargando…
Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling
The interaction dynamics of signaling complexes is emerging as a key determinant that regulates the specificity of cellular responses. We present a combined experimental and computational study that quantifies the consequences of plasma membrane microcompartmentalization for the dynamics of type I i...
Autores principales: | You, Changjiang, Marquez-Lago, Tatiana T., Richter, Christian Paolo, Wilmes, Stephan, Moraga, Ignacio, Garcia, K. Christopher, Leier, André, Piehler, Jacob |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135388/ https://www.ncbi.nlm.nih.gov/pubmed/27957535 http://dx.doi.org/10.1126/sciadv.1600452 |
Ejemplares similares
-
Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments
por: Richter, David, et al.
Publicado: (2017) -
Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling
por: Wilmes, Stephan, et al.
Publicado: (2015) -
Four-color single-molecule imaging with engineered tags resolves the molecular architecture of signaling complexes in the plasma membrane
por: Sotolongo Bellón, Junel, et al.
Publicado: (2022) -
Mapping Determinants of Cytokine Signaling via Protein Engineering
por: Gorby, Claire, et al.
Publicado: (2018) -
Kinetics of cytokine receptor trafficking determine signaling and functional selectivity
por: Martinez-Fabregas, Jonathan, et al.
Publicado: (2019)