Cargando…

A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy – results from a Swedish cohort study

BACKGROUND: To prevent debilitating and irreversible joint damage, rheumatoid arthritis (RA) is often treated with tumor necrosis factor inhibitor (TNFi), but many patients do not respond to this costly therapy. Few predictors for response are known, and it has been proposed that genetic factors whi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Xia, Askling, Johan, Saevarsdottir, Saedis, Padyukov, Leonid, Alfredsson, Lars, Viatte, Sebastien, Frisell, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135751/ https://www.ncbi.nlm.nih.gov/pubmed/27912794 http://dx.doi.org/10.1186/s13075-016-1174-z

Ejemplares similares

Systematic approach demonstrates enrichment of multiple interactions between non-HLA risk variants and HLA-DRB1 risk alleles in rheumatoid arthritis
por: Diaz-Gallo, Lina-Marcela, et al.
Publicado: (2018)

Occupational exposure to asbestos and silica and risk of developing rheumatoid arthritis: findings from a Swedish population-based case-control study
por: Ilar, Anna, et al.
Publicado: (2019)

Patient characteristics influence the choice of biological drug in RA, and will make non-TNFi biologics appear more harmful than TNFi biologics
por: Frisell, Thomas, et al.
Publicado: (2018)

Interaction Analysis between HLA-DRB1 Shared Epitope Alleles and MHC Class II Transactivator CIITA Gene with Regard to Risk of Rheumatoid Arthritis
por: Ronninger, Marcus, et al.
Publicado: (2012)

Oral contraceptives, breastfeeding and the risk of developing rheumatoid arthritis: results from the Swedish EIRA study
por: Orellana, Cecilia, et al.
Publicado: (2017)

Is tea consumption associated with reduction of risk of rheumatoid arthritis? A Swedish case-control study
por: Westerlind, Helga, et al.
Publicado: (2021)

Comorbidities and treatment patterns in early rheumatoid arthritis: a nationwide Swedish study
por: Tidblad, Liselotte, et al.
Publicado: (2022)

Combined Conventional Synthetic Disease Modifying Therapy vs. Infliximab for Rheumatoid Arthritis: Emulating a Randomized Trial in Observational Data
por: Barbulescu, Andrei, et al.
Publicado: (2022)

Postmenopausal hormone therapy and the risk of rheumatoid arthritis: results from the Swedish EIRA population-based case-control study
por: Orellana, Cecilia, et al.
Publicado: (2015)

Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 ‘shared epitope’ alleles
por: Wagner, Catriona A, et al.
Publicado: (2015)

Does persistence to methotrexate treatment in early rheumatoid arthritis have a familial component?
por: Sysojev, Anton Öberg, et al.
Publicado: (2022)

Association of HLA-DRB1 and -DQB1alleles and haplotypes with rheumatoid arthritis in a Pakistani population
por: Muazzam, Ambreen Gul, et al.
Publicado: (2013)

Risk of Thyroxine-Treated Autoimmune Thyroid Disease Associated With Disease Onset in Patients With Rheumatoid Arthritis
por: Waldenlind, Kristin, et al.
Publicado: (2018)

Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers
por: Saevarsdottir, Saedis, et al.
Publicado: (2011)

HLA-DRB1 haplotypes predict cardiovascular mortality in inflammatory polyarthritis independent of CRP and anti-CCP status
por: Sharma, Seema, et al.
Publicado: (2022)

Neither low social support nor low decision latitude at work is associated with disease remission among patients with rheumatoid arthritis: results from the Swedish EIRA study
por: Hedenstierna, Louise, et al.
Publicado: (2022)

The distribution of HLA-A, -B, and -DRB1 alleles and haplotypes in inhabitants of Guizhou Province of China()
por: Pan, Qinqin, et al.
Publicado: (2011)

Anticollagen type II antibodies are associated with an acute onset rheumatoid arthritis phenotype and prognosticate lower degree of inflammation during 5 years follow-up
por: Manivel, Vivek Anand, et al.
Publicado: (2017)

Sleep problems in rheumatoid arthritis over 12 years from diagnosis: results from the Swedish EIRA study
por: Lyne, Lauren, et al.
Publicado: (2022)

Association of HLA-A, B, DRB1 alleles and haplotypes with HIV-1 infection in Chongqing, China
por: Huang, Xia, et al.
Publicado: (2009)

Diversity of Extended HLA-DRB1 Haplotypes in the Finnish Population
por: Wennerström, Annika, et al.
Publicado: (2013)

Does autoimmune thyroid disease affects rheumatoid arthritis disease activity or response to methotrexate?
por: Waldenlind, Kristin, et al.
Publicado: (2020)

Association of Human Leukocyte Antigen (HLA) class II (DRB1 and DQB1) alleles and haplotypes with Rheumatoid Arthritis in Sudanese patients
por: Ali, Adil Ahmed, et al.
Publicado: (2023)

Higher education is associated with a better rheumatoid arthritis outcome concerning for pain and function but not disease activity: results from the EIRA cohort and Swedish rheumatology register
por: Jiang, Xia, et al.
Publicado: (2015)

Quantifying the contribution of the second HLA-DRB1 susceptibility allele to the risk of rheumatoid arthritis: a meta-analysis
por: van Rossum, IA, et al.
Publicado: (2005)

Association of HLA-DRB1, DQA1 and DQB1 Alleles and Haplotypes with Common Variable Immunodeficiency in Iranian Patients
por: Amanzadeh, Amir, et al.
Publicado: (2012)

An Analysis of HLA-A, -B, and -DRB1 Allele and Haplotype Frequencies of 21,918 Residents Living in Liaoning, China
por: Li, Xiao-Feng, et al.
Publicado: (2014)

Determination of HLA‐A, ‐C, ‐B, ‐DRB1 allele and haplotype frequency in Japanese population based on family study
por: Ikeda, N., et al.
Publicado: (2015)

Determination of HLA‐A, ‐B, ‐C, ‐DRB1 and ‐DQB1 allele and haplotype frequencies in heart failure patients
por: Roura, Santiago, et al.
Publicado: (2019)

Identification of a two-SNP PLA2R1 Haplotype and HLA-DRB1 Alleles as Primary Risk Associations in Idiopathic Membranous Nephropathy
por: Latt, Khun Zaw, et al.
Publicado: (2018)

Parity influences the severity of ACPA-negative early rheumatoid arthritis: a cohort study based on the Swedish EIRA material
por: Pikwer, Mitra, et al.
Publicado: (2015)

Frequency of HLA-DRB1 alleles in rheumatoid arthritis patients in Zahedan, southeast Iran
por: Sandoughi, Mahnaz, et al.
Publicado: (2011)

HLA-A, B and DRB1 allele and haplotype frequencies in volunteer bone marrow donors from the north of Parana State
por: Bardi, Marlene Silva, et al.
Publicado: (2012)

HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotype frequencies in Lebanese and their relatedness to neighboring and distant populations
por: Almawi, Wassim Y., et al.
Publicado: (2022)

The increased risk of multiple sclerosis associated with HLA-DRB1*15:01 and smoking is modified by alcohol consumption
por: Hedström, Anna Karin, et al.
Publicado: (2021)

Allergic conditions and risk of rheumatoid arthritis: a Swedish case–control study
por: Kronzer, Vanessa L, et al.
Publicado: (2022)

Complex Relationships of Smoking, HLA–DRB1 Genes, and Serologic Profiles in Patients With Early Rheumatoid Arthritis: Update From a Swedish Population‐Based Case–Control Study
por: Hedström, Anna Karin, et al.
Publicado: (2019)

Variation in Effects of Non-Hodgkin Lymphoma Risk Factors According to the Human Leukocyte Antigen (HLA)-DRB1*01:01 Allele and Ancestral Haplotype 8.1
por: Wang, Sophia S., et al.
Publicado: (2011)

Lower Frequency of HLA-DRB1 Type 1 Diabetes Risk Alleles in Pediatric Patients with MODY
por: Urrutia, Inés, et al.
Publicado: (2017)

Allele Polymorphism and Haplotype Diversity of HLA-A, -B and -DRB1 Loci in Sequence-Based Typing for Chinese Uyghur Ethnic Group
por: Shen, Chun-mei, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_lsldt2md97q2cqooqpai1d964m