Association of serum ferritin levels with smoking and lung function in the Korean adult population: analysis of the fourth and fifth Korean National Health and Nutrition Examination Survey
BACKGROUND: Iron-catalyzed oxidative stress contributes to lung injury after exposure to various toxins, including cigarette smoke. An oxidant/antioxidant imbalance is considered to play a critical role in the pathogenesis of COPD. Ferritin is a key protein in iron homeostasis, and its capacity to o...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136357/ https://www.ncbi.nlm.nih.gov/pubmed/27942209 http://dx.doi.org/10.2147/COPD.S116982 |
_version_ | 1782471706767523840 |
---|---|
author | Lee, Chan Ho Goag, Eun Kyung Lee, Su Hwan Chung, Kyung Soo Jung, Ji Ye Park, Moo Suk Kim, Young Sam Kim, Se Kyu Chang, Joon Song, Joo Han |
author_facet | Lee, Chan Ho Goag, Eun Kyung Lee, Su Hwan Chung, Kyung Soo Jung, Ji Ye Park, Moo Suk Kim, Young Sam Kim, Se Kyu Chang, Joon Song, Joo Han |
author_sort | Lee, Chan Ho |
collection | PubMed |
description | BACKGROUND: Iron-catalyzed oxidative stress contributes to lung injury after exposure to various toxins, including cigarette smoke. An oxidant/antioxidant imbalance is considered to play a critical role in the pathogenesis of COPD. Ferritin is a key protein in iron homeostasis, and its capacity to oxidize and sequester the metal preventing iron prooxidant activity implicates its possible role in the alteration of antioxidant imbalance. We investigated the relationship among cigarette smoking, lung function, and serum ferritin concentration in a large cohort representative of the Korean adult population. MATERIALS AND METHODS: Among 50,405 participants of the Korean National Health and Nutrition Examination Survey from 2010 to 2014, 15,239 adult subjects older than 40 years with serum ferritin levels and spirometric data were selected for this study. RESULTS: The mean age was 56.5 years for men (43%) and 56.9 years for women (57%). The prevalence of airway obstruction was 13.4%, which was significantly higher in men than in women, and increased in former or current smokers. The median levels of serum ferritin were highest in the airway obstruction group, followed by the restrictive pattern group, and lowest in the normal lung function group. The median ferritin levels were increased by smoking status and amounts in each spirometric subgroup. In multivariable regression analysis, serum ferritin was positively associated with forced expiratory volume in 1 second and forced expiratory volume in 1 second/forced vital capacity, whereas the smoking amount was negatively associated with the adjustment with age, sex, height, and weight. CONCLUSION: Serum ferritin levels were increased in former or current smokers and were increased with smoking amount in all subgroups of participants categorized according to spirometric results. The result was also evident in the subgroups divided by obstructive severity. While smoking amount was inversely related to lung function, higher levels of serum ferritin were associated with enhanced spirometric results in a representative sample of the general Korean adult population. Future prospective studies will be needed to clarify the causality between serum ferritin and lung functions and their role in COPD morbidity. |
format | Online Article Text |
id | pubmed-5136357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-51363572016-12-09 Association of serum ferritin levels with smoking and lung function in the Korean adult population: analysis of the fourth and fifth Korean National Health and Nutrition Examination Survey Lee, Chan Ho Goag, Eun Kyung Lee, Su Hwan Chung, Kyung Soo Jung, Ji Ye Park, Moo Suk Kim, Young Sam Kim, Se Kyu Chang, Joon Song, Joo Han Int J Chron Obstruct Pulmon Dis Original Research BACKGROUND: Iron-catalyzed oxidative stress contributes to lung injury after exposure to various toxins, including cigarette smoke. An oxidant/antioxidant imbalance is considered to play a critical role in the pathogenesis of COPD. Ferritin is a key protein in iron homeostasis, and its capacity to oxidize and sequester the metal preventing iron prooxidant activity implicates its possible role in the alteration of antioxidant imbalance. We investigated the relationship among cigarette smoking, lung function, and serum ferritin concentration in a large cohort representative of the Korean adult population. MATERIALS AND METHODS: Among 50,405 participants of the Korean National Health and Nutrition Examination Survey from 2010 to 2014, 15,239 adult subjects older than 40 years with serum ferritin levels and spirometric data were selected for this study. RESULTS: The mean age was 56.5 years for men (43%) and 56.9 years for women (57%). The prevalence of airway obstruction was 13.4%, which was significantly higher in men than in women, and increased in former or current smokers. The median levels of serum ferritin were highest in the airway obstruction group, followed by the restrictive pattern group, and lowest in the normal lung function group. The median ferritin levels were increased by smoking status and amounts in each spirometric subgroup. In multivariable regression analysis, serum ferritin was positively associated with forced expiratory volume in 1 second and forced expiratory volume in 1 second/forced vital capacity, whereas the smoking amount was negatively associated with the adjustment with age, sex, height, and weight. CONCLUSION: Serum ferritin levels were increased in former or current smokers and were increased with smoking amount in all subgroups of participants categorized according to spirometric results. The result was also evident in the subgroups divided by obstructive severity. While smoking amount was inversely related to lung function, higher levels of serum ferritin were associated with enhanced spirometric results in a representative sample of the general Korean adult population. Future prospective studies will be needed to clarify the causality between serum ferritin and lung functions and their role in COPD morbidity. Dove Medical Press 2016-11-29 /pmc/articles/PMC5136357/ /pubmed/27942209 http://dx.doi.org/10.2147/COPD.S116982 Text en © 2016 Lee et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Lee, Chan Ho Goag, Eun Kyung Lee, Su Hwan Chung, Kyung Soo Jung, Ji Ye Park, Moo Suk Kim, Young Sam Kim, Se Kyu Chang, Joon Song, Joo Han Association of serum ferritin levels with smoking and lung function in the Korean adult population: analysis of the fourth and fifth Korean National Health and Nutrition Examination Survey |
title | Association of serum ferritin levels with smoking and lung function in the Korean adult population: analysis of the fourth and fifth Korean National Health and Nutrition Examination Survey |
title_full | Association of serum ferritin levels with smoking and lung function in the Korean adult population: analysis of the fourth and fifth Korean National Health and Nutrition Examination Survey |
title_fullStr | Association of serum ferritin levels with smoking and lung function in the Korean adult population: analysis of the fourth and fifth Korean National Health and Nutrition Examination Survey |
title_full_unstemmed | Association of serum ferritin levels with smoking and lung function in the Korean adult population: analysis of the fourth and fifth Korean National Health and Nutrition Examination Survey |
title_short | Association of serum ferritin levels with smoking and lung function in the Korean adult population: analysis of the fourth and fifth Korean National Health and Nutrition Examination Survey |
title_sort | association of serum ferritin levels with smoking and lung function in the korean adult population: analysis of the fourth and fifth korean national health and nutrition examination survey |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136357/ https://www.ncbi.nlm.nih.gov/pubmed/27942209 http://dx.doi.org/10.2147/COPD.S116982 |
work_keys_str_mv | AT leechanho associationofserumferritinlevelswithsmokingandlungfunctioninthekoreanadultpopulationanalysisofthefourthandfifthkoreannationalhealthandnutritionexaminationsurvey AT goageunkyung associationofserumferritinlevelswithsmokingandlungfunctioninthekoreanadultpopulationanalysisofthefourthandfifthkoreannationalhealthandnutritionexaminationsurvey AT leesuhwan associationofserumferritinlevelswithsmokingandlungfunctioninthekoreanadultpopulationanalysisofthefourthandfifthkoreannationalhealthandnutritionexaminationsurvey AT chungkyungsoo associationofserumferritinlevelswithsmokingandlungfunctioninthekoreanadultpopulationanalysisofthefourthandfifthkoreannationalhealthandnutritionexaminationsurvey AT jungjiye associationofserumferritinlevelswithsmokingandlungfunctioninthekoreanadultpopulationanalysisofthefourthandfifthkoreannationalhealthandnutritionexaminationsurvey AT parkmoosuk associationofserumferritinlevelswithsmokingandlungfunctioninthekoreanadultpopulationanalysisofthefourthandfifthkoreannationalhealthandnutritionexaminationsurvey AT kimyoungsam associationofserumferritinlevelswithsmokingandlungfunctioninthekoreanadultpopulationanalysisofthefourthandfifthkoreannationalhealthandnutritionexaminationsurvey AT kimsekyu associationofserumferritinlevelswithsmokingandlungfunctioninthekoreanadultpopulationanalysisofthefourthandfifthkoreannationalhealthandnutritionexaminationsurvey AT changjoon associationofserumferritinlevelswithsmokingandlungfunctioninthekoreanadultpopulationanalysisofthefourthandfifthkoreannationalhealthandnutritionexaminationsurvey AT songjoohan associationofserumferritinlevelswithsmokingandlungfunctioninthekoreanadultpopulationanalysisofthefourthandfifthkoreannationalhealthandnutritionexaminationsurvey |