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Choices have consequences: the nexus between DNA repair pathways and genomic instability in cancer

BACKGROUND: The genome is under constant assault from a multitude of sources that can lead to the formation of DNA double-stand breaks (DSBs). DSBs are cytotoxic lesions, which if left unrepaired could lead to genomic instability, cancer and even cell death. However, erroneous repair of DSBs can lea...

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Detalles Bibliográficos
Autores principales: Bhattacharjee, Sonali, Nandi, Saikat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136664/
https://www.ncbi.nlm.nih.gov/pubmed/27921283
http://dx.doi.org/10.1186/s40169-016-0128-z