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Choices have consequences: the nexus between DNA repair pathways and genomic instability in cancer
BACKGROUND: The genome is under constant assault from a multitude of sources that can lead to the formation of DNA double-stand breaks (DSBs). DSBs are cytotoxic lesions, which if left unrepaired could lead to genomic instability, cancer and even cell death. However, erroneous repair of DSBs can lea...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Berlin Heidelberg
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136664/ https://www.ncbi.nlm.nih.gov/pubmed/27921283 http://dx.doi.org/10.1186/s40169-016-0128-z |