Relocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactions

The expression of polyspecific membrane transporters is one important mechanism by which cells can obtain resistance to structurally different antibiotics and cytotoxic agents. These transporters reduce intracellular drug concentrations to subtoxic levels by mediating drug efflux across the cell env...

Descripción completa

Detalles Bibliográficos
Autores principales: Nair, Asha V., Singh, Himansha, Raturi, Sagar, Neuberger, Arthur, Tong, Zhen, Ding, Ning, Agboh, Kelvin, van Veen, Hendrik W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137110/
https://www.ncbi.nlm.nih.gov/pubmed/27917857
http://dx.doi.org/10.1038/srep38052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137110/
https://www.ncbi.nlm.nih.gov/pubmed/27917857
http://dx.doi.org/10.1038/srep38052

Ejemplares similares