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Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance

The role of Sox2 in neurosensory development is not yet fully understood. Using mice with conditional Islet1-cre mediated deletion of Sox2, we explored the function of Sox2 in neurosensory development in a model with limited cell type diversification, the inner ear. In Sox2 conditional mutants, neur...

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Autores principales: Dvorakova, Martina, Jahan, Israt, Macova, Iva, Chumak, Tetyana, Bohuslavova, Romana, Syka, Josef, Fritzsch, Bernd, Pavlinkova, Gabriela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137136/
https://www.ncbi.nlm.nih.gov/pubmed/27917898
http://dx.doi.org/10.1038/srep38253
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author Dvorakova, Martina
Jahan, Israt
Macova, Iva
Chumak, Tetyana
Bohuslavova, Romana
Syka, Josef
Fritzsch, Bernd
Pavlinkova, Gabriela
author_facet Dvorakova, Martina
Jahan, Israt
Macova, Iva
Chumak, Tetyana
Bohuslavova, Romana
Syka, Josef
Fritzsch, Bernd
Pavlinkova, Gabriela
author_sort Dvorakova, Martina
collection PubMed
description The role of Sox2 in neurosensory development is not yet fully understood. Using mice with conditional Islet1-cre mediated deletion of Sox2, we explored the function of Sox2 in neurosensory development in a model with limited cell type diversification, the inner ear. In Sox2 conditional mutants, neurons initially appear to form normally, whereas late- differentiating neurons of the cochlear apex never form. Variable numbers of hair cells differentiate in the utricle, saccule, and cochlear base but sensory epithelium formation is completely absent in the apex and all three cristae of the semicircular canal ampullae. Hair cells differentiate only in sensory epithelia known or proposed to have a lineage relationship of neurons and hair cells. All initially formed neurons lacking hair cell targets die by apoptosis days after they project toward non-existing epithelia. Therefore, late neuronal development depends directly on Sox2 for differentiation and on the survival of hair cells, possibly derived from common neurosensory precursors.
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spelling pubmed-51371362017-01-27 Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance Dvorakova, Martina Jahan, Israt Macova, Iva Chumak, Tetyana Bohuslavova, Romana Syka, Josef Fritzsch, Bernd Pavlinkova, Gabriela Sci Rep Article The role of Sox2 in neurosensory development is not yet fully understood. Using mice with conditional Islet1-cre mediated deletion of Sox2, we explored the function of Sox2 in neurosensory development in a model with limited cell type diversification, the inner ear. In Sox2 conditional mutants, neurons initially appear to form normally, whereas late- differentiating neurons of the cochlear apex never form. Variable numbers of hair cells differentiate in the utricle, saccule, and cochlear base but sensory epithelium formation is completely absent in the apex and all three cristae of the semicircular canal ampullae. Hair cells differentiate only in sensory epithelia known or proposed to have a lineage relationship of neurons and hair cells. All initially formed neurons lacking hair cell targets die by apoptosis days after they project toward non-existing epithelia. Therefore, late neuronal development depends directly on Sox2 for differentiation and on the survival of hair cells, possibly derived from common neurosensory precursors. Nature Publishing Group 2016-12-05 /pmc/articles/PMC5137136/ /pubmed/27917898 http://dx.doi.org/10.1038/srep38253 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Dvorakova, Martina
Jahan, Israt
Macova, Iva
Chumak, Tetyana
Bohuslavova, Romana
Syka, Josef
Fritzsch, Bernd
Pavlinkova, Gabriela
Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance
title Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance
title_full Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance
title_fullStr Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance
title_full_unstemmed Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance
title_short Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance
title_sort incomplete and delayed sox2 deletion defines residual ear neurosensory development and maintenance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137136/
https://www.ncbi.nlm.nih.gov/pubmed/27917898
http://dx.doi.org/10.1038/srep38253
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