Novel human mutation and CRISPR/Cas genome-edited mice reveal the importance of C-terminal domain of MSX1 in tooth and palate development

Several mutations, located mainly in the MSX1 homeodomain, have been identified in non-syndromic tooth agenesis predominantly affecting premolars and third molars. We identified a novel frameshift mutation of the highly conserved C-terminal domain of MSX1, known as Msx homology domain 6 (MH6), in a...

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Detalles Bibliográficos
Autores principales: Mitsui, Silvia Naomi, Yasue, Akihiro, Masuda, Kiyoshi, Naruto, Takuya, Minegishi, Yoshiyuki, Oyadomari, Seiichi, Noji, Sumihare, Imoto, Issei, Tanaka, Eiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137164/
https://www.ncbi.nlm.nih.gov/pubmed/27917906
http://dx.doi.org/10.1038/srep38398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137164/
https://www.ncbi.nlm.nih.gov/pubmed/27917906
http://dx.doi.org/10.1038/srep38398

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