Novel TDP2-ubiquitin interactions and their importance for the repair of topoisomerase II-mediated DNA damage

Tyrosyl DNA phosphodiesterase 2 (TDP2) is a multifunctional protein implicated in DNA repair, signal transduction and transcriptional regulation. In its DNA repair role, TDP2 safeguards genome integrity by hydrolyzing 5′-tyrosyl DNA adducts formed by abortive topoisomerase II (Top2) cleavage complex...

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Detalles Bibliográficos
Autores principales: Rao, Timsi, Gao, Rui, Takada, Saeko, Al Abo, Muthana, Chen, Xiang, Walters, Kylie J., Pommier, Yves, Aihara, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137425/
https://www.ncbi.nlm.nih.gov/pubmed/27543075
http://dx.doi.org/10.1093/nar/gkw719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137425/
https://www.ncbi.nlm.nih.gov/pubmed/27543075
http://dx.doi.org/10.1093/nar/gkw719

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