Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications

Mutations in human zinc-finger transcription factor WT1 result in abnormal development of the kidneys and genitalia and an array of pediatric problems including nephropathy, blastoma, gonadal dysgenesis and genital discordance. Several overlapping phenotypes are associated with WT1 mutations, includ...

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Detalles Bibliográficos
Autores principales: Hashimoto, Hideharu, Zhang, Xing, Zheng, Yu, Wilson, Geoffrey G., Cheng, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137435/
https://www.ncbi.nlm.nih.gov/pubmed/27596598
http://dx.doi.org/10.1093/nar/gkw766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137435/
https://www.ncbi.nlm.nih.gov/pubmed/27596598
http://dx.doi.org/10.1093/nar/gkw766

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