Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues

Thymine DNA Glycosylase (TDG) is a base excision repair enzyme functioning in DNA repair and epigenetic regulation. TDG removes thymine from mutagenic G·T mispairs arising from deamination of 5-methylcytosine (mC), and it processes other deamination-derived lesions including uracil (U). Essential fo...

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Detalles Bibliográficos
Autores principales: Coey, Christopher T., Malik, Shuja S., Pidugu, Lakshmi S., Varney, Kristen M., Pozharski, Edwin, Drohat, Alexander C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137436/
https://www.ncbi.nlm.nih.gov/pubmed/27580719
http://dx.doi.org/10.1093/nar/gkw768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137436/
https://www.ncbi.nlm.nih.gov/pubmed/27580719
http://dx.doi.org/10.1093/nar/gkw768

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