Cargando…

Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance

Telomeres are specialized nucleoprotein complexes that comprise the ends of linear chromosomes. Human telomeres end in a short, single-stranded DNA (ssDNA) overhang that is recognized and bound by two telomere proteins, POT1 and TPP1. Whereas POT1 binds directly to telomere ssDNA, its interaction wi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rajavel, Malligarjunan, Orban, Tivadar, Xu, Mengyuan, Hernandez-Sanchez, Wilnelly, de la Fuente, Maria, Palczewski, Krzysztof, Taylor, Derek J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137443/ https://www.ncbi.nlm.nih.gov/pubmed/27655633 http://dx.doi.org/10.1093/nar/gkw846

Ejemplares similares

POT1-TPP1 differentially regulates telomerase via POT1 His266 and as a function of single-stranded telomere DNA length
por: Xu, Mengyuan, et al.
Publicado: (2019)

Multiple hPOT1–TPP1 cooperatively unfold contiguous telomeric G-quadruplexes proceeding from 3′ toward 5′, a feature due to a 3′-end binding preference and to structuring of telomeric DNA
por: Chatain, Jean, et al.
Publicado: (2021)

POT1-TPP1 binding stabilizes POT1, promoting efficient telomere maintenance
por: Aramburu, Tomas, et al.
Publicado: (2022)

Observation of long-range tertiary interactions during ligand binding by the TPP riboswitch aptamer
por: Duesterberg, Van K, et al.
Publicado: (2015)

POT1-TPP1 telomere length regulation and disease
por: Aramburu, Tomas, et al.
Publicado: (2020)

Structural and functional analysis of an OB-fold in human Ctc1 implicated in telomere maintenance and bone marrow syndromes
por: Shastrula, Prashanth K, et al.
Publicado: (2018)

Modern genome editing meets telomeres: the many functions of TPP1
por: Karlseder, Jan
Publicado: (2014)

Role of Bacillus subtilis BacB in the Synthesis of Bacilysin
por: Rajavel, Malligarjunan, et al.
Publicado: (2009)

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity
por: Nandakumar, Jayakrishnan, et al.
Publicado: (2012)

Structural and functional analysis of the human POT1-TPP1 telomeric complex
por: Rice, Cory, et al.
Publicado: (2017)

Mitoribosomal Deregulation Drives Senescence via TPP1-Mediated Telomere Deprotection
por: Min, Seongki, et al.
Publicado: (2022)

Telomere-Binding Protein TPP1 Modulates Telomere Homeostasis and Confers Radioresistance to Human Colorectal Cancer Cells
por: Yang, Lei, et al.
Publicado: (2013)

Structure of the human telomere in Na(+) solution: an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity
por: Lim, Kah Wai, et al.
Publicado: (2013)

Zebrafish as a Model System to Study the Physiological Function of Telomeric Protein TPP1
por: Xie, Yiying, et al.
Publicado: (2011)

The TPP scheduler
por: Marrocchesi, P S, et al.
Publicado: (1987)

Unique C. elegans telomeric overhang structures reveal the evolutionarily conserved properties of telomeric DNA
por: Školáková, Petra, et al.
Publicado: (2015)

Structure-Based Phylogeny as a Diagnostic for Functional Characterization of Proteins with a Cupin Fold
por: Agarwal, Garima, et al.
Publicado: (2009)

Correction: Zebrafish as a Model System to Study the Physiological Function of Telomeric Protein TPP1
por: Xie, Yiying, et al.
Publicado: (2011)

CTC1 OB-B interaction with TPP1 terminates telomerase and prevents telomere overextension
por: Wang, Huan, et al.
Publicado: (2023)

The TPP Is Dead, Long Live the TPP? A Response to Recent Commentaries
por: Labonté, Ronald, et al.
Publicado: (2017)

Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K(+) solution: insights into structure polymorphism of the human telomeric sequence
por: Dai, Jixun, et al.
Publicado: (2007)

ALEPH - TPP TPPLIB
por: Marrocchesi, P S
Publicado: (1989)

TPP software outline
por: Amendolia, S R, et al.
Publicado: (1987)

Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1
por: Kocak, Hande, et al.
Publicado: (2014)

Elucidation of the mode of interaction in the UP1–telomerase RNA–telomeric DNA ternary complex which serves to recruit telomerase to telomeric DNA and to enhance the telomerase activity
por: Nagata, Takashi, et al.
Publicado: (2008)

Structural diversity of target-specific homopyrimidine peptide nucleic acid–dsDNA complexes
por: Bentin, Thomas, et al.
Publicado: (2006)

Natural isoflavones regulate the quadruplex–duplex competition in human telomeric DNA
por: Zhang, Jin-li, et al.
Publicado: (2009)

Arrangements of human telomere DNA quadruplex in physiologically relevant K(+) solutions
por: Renčiuk, D., et al.
Publicado: (2009)

Dynamics and stability of polymorphic human telomeric G-quadruplex under tension
por: You, Huijuan, et al.
Publicado: (2014)

Insights into telomeric G-quadruplex DNA recognition by HMGB1 protein
por: Amato, Jussara, et al.
Publicado: (2019)

The solution structures of higher-order human telomere G-quadruplex multimers
por: Monsen, Robert C, et al.
Publicado: (2021)

Structure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K(+) solution: insights into the interconversion of human telomeric G-quadruplex structures
por: Zhang, Zhenjiang, et al.
Publicado: (2010)

Tpz1(TPP)(1) SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association
por: Garg, Mansi, et al.
Publicado: (2014)

Ccq1-Tpz1(TPP1) interaction facilitates telomerase and SHREC association with telomeres in fission yeast
por: Moser, Bettina A., et al.
Publicado: (2015)

The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function
por: Rai, Rekha, et al.
Publicado: (2019)

The TPP Fastbus Library FBLIB
por: Lusiani, A
Publicado: (1993)

G-quadruplex preferentially forms at the very 3′ end of vertebrate telomeric DNA
por: Tang, Jun, et al.
Publicado: (2008)

A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex
por: Collie, Gavin W., et al.
Publicado: (2010)

A direct view of the complex multi-pathway folding of telomeric G-quadruplexes
por: Aznauryan, Mikayel, et al.
Publicado: (2016)

Pre-folded structures govern folding pathways of human telomeric G-quadruplexes
por: Frelih, Tjaša, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_o0n3bg6otnh8u20ifop68mqidg