Cargando…
The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair
Histone/protein deacetylases play multiple roles in regulating gene expression and protein activation and stability. Their deregulation during cancer initiation and progression cause resistance to therapy. Here, we review the role of histone deacetylases (HDACs) and the NAD(+) dependent sirtuins (SI...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137451/ https://www.ncbi.nlm.nih.gov/pubmed/27738139 http://dx.doi.org/10.1093/nar/gkw922 |