Localized structural frustration for evaluating the impact of sequence variants

Population-scale sequencing is increasingly uncovering large numbers of rare single-nucleotide variants (SNVs) in coding regions of the genome. The rarity of these variants makes it challenging to evaluate their deleteriousness with conventional phenotype–genotype associations. Protein structures pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumar, Sushant, Clarke, Declan, Gerstein, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137452/
https://www.ncbi.nlm.nih.gov/pubmed/27915290
http://dx.doi.org/10.1093/nar/gkw927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137452/
https://www.ncbi.nlm.nih.gov/pubmed/27915290
http://dx.doi.org/10.1093/nar/gkw927

Ejemplares similares