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Localized structural frustration for evaluating the impact of sequence variants
Population-scale sequencing is increasingly uncovering large numbers of rare single-nucleotide variants (SNVs) in coding regions of the genome. The rarity of these variants makes it challenging to evaluate their deleteriousness with conventional phenotype–genotype associations. Protein structures pr...
Autores principales: | Kumar, Sushant, Clarke, Declan, Gerstein, Mark |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137452/ https://www.ncbi.nlm.nih.gov/pubmed/27915290 http://dx.doi.org/10.1093/nar/gkw927 |
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