Molecular mechanism of divalent-metal-induced activation of NS3 helicase and insights into Zika virus inhibitor design

Zika virus has attracted increasing attention because of its potential for causing human neural disorders, including microcephaly in infants and Guillain–Barré syndrome. Its NS3 helicase domain plays critical roles in NTP-dependent RNA unwinding and translocation during viral replication. Our struct...

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Detalles Bibliográficos
Autores principales: Cao, Xiaocong, Li, Yajuan, Jin, Xiangyu, Li, Yuelong, Guo, Feng, Jin, Tengchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137455/
https://www.ncbi.nlm.nih.gov/pubmed/27915293
http://dx.doi.org/10.1093/nar/gkw941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137455/
https://www.ncbi.nlm.nih.gov/pubmed/27915293
http://dx.doi.org/10.1093/nar/gkw941

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