Cargando…

Molecular mechanism of divalent-metal-induced activation of NS3 helicase and insights into Zika virus inhibitor design

Zika virus has attracted increasing attention because of its potential for causing human neural disorders, including microcephaly in infants and Guillain–Barré syndrome. Its NS3 helicase domain plays critical roles in NTP-dependent RNA unwinding and translocation during viral replication. Our struct...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cao, Xiaocong, Li, Yajuan, Jin, Xiangyu, Li, Yuelong, Guo, Feng, Jin, Tengchuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137455/ https://www.ncbi.nlm.nih.gov/pubmed/27915293 http://dx.doi.org/10.1093/nar/gkw941

Ejemplares similares

Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways
por: Li, Yajuan, et al.
Publicado: (2017)

Sinorhizobium meliloti YrbA binds divalent metal cations using two conserved histidines
por: Roret, Thomas, et al.
Publicado: (2020)

Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5
por: Newman, Joseph A., et al.
Publicado: (2017)

Insights into the structural and mechanistic basis of multifunctional S. cerevisiae Pif1p helicase
por: Lu, Ke-Yu, et al.
Publicado: (2018)

Differential stability of DNA crossovers in solution mediated by divalent cations
por: Várnai, Péter, et al.
Publicado: (2010)

Insights into the structure and assembly of the Bacillus subtilis clamp-loader complex and its interaction with the replicative helicase
por: Afonso, José P., et al.
Publicado: (2013)

Study of the DnaB:DciA interplay reveals insights into the primary mode of loading of the bacterial replicative helicase
por: Marsin, Stéphanie, et al.
Publicado: (2021)

Structural fluctuation observed in Z-DNA d(CGCGCG)(2) in the absence of divalent metal cations and polyamines
por: Chatake, Toshiyuki
Publicado: (2013)

Mechanistic insight into the assembly of the HerA–NurA helicase–nuclease DNA end resection complex
por: Ahdash, Zainab, et al.
Publicado: (2017)

Elastic properties and secondary structure formation of single-stranded DNA at monovalent and divalent salt conditions
por: Bosco, Alessandro, et al.
Publicado: (2014)

Structure of NS3 helicase from Zika virus
por: Jain, Rinku, et al.
Publicado: (2016)

Structural and functional insights into DNA-end processing by the archaeal HerA helicase–NurA nuclease complex
por: Blackwood, John K., et al.
Publicado: (2012)

A novel zinc-binding fold in the helicase interaction domain of the Bacillus subtilis DnaI helicase loader
por: Loscha, Karin V., et al.
Publicado: (2009)

Structural insights into RISC assembly facilitated by dsRNA-binding domains of human RNA helicase A (DHX9)
por: Fu, Qinqin, et al.
Publicado: (2013)

Mechanistic Insights into Zika Virus NS3 Helicase Inhibition by Epigallocatechin-3-Gallate
por: Kumar, Deepak, et al.
Publicado: (2020)

Structural and dynamic basis of DNA capture and translocation by mitochondrial Twinkle helicase
por: Li, Zhuo, et al.
Publicado: (2022)

Structural basis of the Methanothermobacter thermautotrophicus MCM helicase activity
por: Costa, Alessandro, et al.
Publicado: (2006)

The hexameric structure of the human mitochondrial replicative helicase Twinkle
por: Fernández-Millán, Pablo, et al.
Publicado: (2015)

Molecular docking and simulation of Zika virus NS3 helicase
por: Badshah, Syed Lal, et al.
Publicado: (2019)

Structural insight into how the human helicase subunit MCM2 may act as a histone chaperone together with ASF1 at the replication fork
por: Richet, Nicolas, et al.
Publicado: (2015)

The crystal structure of the Thermus aquaticus DnaB helicase monomer
por: Bailey, Scott, et al.
Publicado: (2007)

Structural and mechanistic insights into the MCM8/9 helicase complex
por: Weng, Zhuangfeng, et al.
Publicado: (2023)

H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing
por: Shahul Hameed, Umar F, et al.
Publicado: (2019)

The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-interaction coordinator during snRNP assembly and recycling
por: Bergfort, Alexandra, et al.
Publicado: (2022)

Structural basis of the XPB helicase–Bax1 nuclease complex interacting with the repair bubble DNA
por: He, Feng, et al.
Publicado: (2020)

Structure and primase-mediated activation of a bacterial dodecameric replicative helicase
por: Bazin, Alexandre, et al.
Publicado: (2015)

Structural basis for DNA strand separation by a hexameric replicative helicase
por: Chaban, Yuriy, et al.
Publicado: (2015)

Structure of mycobacterial 3′-to-5′ RNA:DNA helicase Lhr bound to a ssDNA tracking strand highlights distinctive features of a novel family of bacterial helicases
por: Ejaz, Anam, et al.
Publicado: (2018)

Structural insights into regulation of CNNM-TRPM7 divalent cation uptake by the small GTPase ARL15
por: Mahbub, Luba, et al.
Publicado: (2023)

Structural basis of the XPB–Bax1 complex as a dynamic helicase–nuclease machinery for DNA repair
por: DuPrez, Kevin, et al.
Publicado: (2020)

ATP dependent NS3 helicase interaction with RNA: insights from molecular simulations
por: Pérez-Villa, Andrea, et al.
Publicado: (2015)

Structural basis for osmotic regulation of the DNA binding properties of H-NS proteins
por: Qin, Liang, et al.
Publicado: (2020)

Novel anti-repression mechanism of H-NS proteins by a phage protein
por: Bdira, Fredj Ben, et al.
Publicado: (2021)

Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase
por: Dehghani-Tafti, Saba, et al.
Publicado: (2019)

A skipping rope translocation mechanism in a widespread family of DNA repair helicases
por: Roske, Johann J, et al.
Publicado: (2020)

Staphylococcal self-loading helicases couple the staircase mechanism with inter domain high flexibility
por: Qiao, Cuncun, et al.
Publicado: (2022)

Zika virus NS3 is a canonical RNA helicase stimulated by NS5 RNA polymerase
por: Xu, Shan, et al.
Publicado: (2019)

Papillomavirus E1 helicase assembly maintains an asymmetric state in the absence of DNA and nucleotide cofactors
por: Sanders, Cyril M., et al.
Publicado: (2007)

A flexible brace maintains the assembly of a hexameric replicative helicase during DNA unwinding
por: Whelan, Fiona, et al.
Publicado: (2012)

The Ighmbp2 helicase structure reveals the molecular basis for disease-causing mutations in DMSA1
por: Lim, Siew Choo, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_mbqoknedkhcphp83daltgnec6t