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Modification of orthogonal tRNAs: unexpected consequences for sense codon reassignment

Breaking the degeneracy of the genetic code via sense codon reassignment has emerged as a way to incorporate multiple copies of multiple non-canonical amino acids into a protein of interest. Here, we report the modification of a normally orthogonal tRNA by a host enzyme and show that this adventitio...

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Detalles Bibliográficos
Autores principales: Biddle, Wil, Schmitt, Margaret A., Fisk, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137457/
https://www.ncbi.nlm.nih.gov/pubmed/27915288
http://dx.doi.org/10.1093/nar/gkw948