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Interaction between hypoxia, AKT and HIF-1 signaling in HNSCC and NSCLC: implications for future treatment strategies

BACKGROUND: Hypoxia is a negative prognostic factor and this study investigated the relationship between hypoxia, hypoxia inducible factor 1 (HIF-1) and AKT signaling in head and neck squamous cell carcinoma (HNSCC) and non-small-cell lung cancer (NSCLC). RESULTS/METHODOLOGY: pAKT was induced by hyp...

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Detalles Bibliográficos
Autores principales: Stegeman, Hanneke, Span, Paul N, Peeters, Wenny JM, Verheijen, Marieke MG, Grénman, Reidar, Meijer, Tineke WH, Kaanders, Johannes HAM, Bussink, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137923/
https://www.ncbi.nlm.nih.gov/pubmed/28031935
http://dx.doi.org/10.4155/fso.15.84