Cargando…

Interaction between hypoxia, AKT and HIF-1 signaling in HNSCC and NSCLC: implications for future treatment strategies

BACKGROUND: Hypoxia is a negative prognostic factor and this study investigated the relationship between hypoxia, hypoxia inducible factor 1 (HIF-1) and AKT signaling in head and neck squamous cell carcinoma (HNSCC) and non-small-cell lung cancer (NSCLC). RESULTS/METHODOLOGY: pAKT was induced by hyp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stegeman, Hanneke, Span, Paul N, Peeters, Wenny JM, Verheijen, Marieke MG, Grénman, Reidar, Meijer, Tineke WH, Kaanders, Johannes HAM, Bussink, Johan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Future Science Ltd 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137923/ https://www.ncbi.nlm.nih.gov/pubmed/28031935 http://dx.doi.org/10.4155/fso.15.84

Ejemplares similares

Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines
por: Stegeman, Hanneke, et al.
Publicado: (2013)

Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck
por: Stegeman, Hanneke, et al.
Publicado: (2012)

αB-crystallin stimulates VEGF secretion and tumor cell migration and correlates with enhanced distant metastasis in head and neck squamous cell carcinoma
por: van de Schootbrugge, Chantal, et al.
Publicado: (2013)

Effect of hypoxia on the expression of αB-crystallin in head and neck squamous cell carcinoma
por: van de Schootbrugge, Chantal, et al.
Publicado: (2014)

Glucose and glutamine metabolism in relation to mutational status in NSCLC histological subtypes
por: Meijer, Tineke W.H., et al.
Publicado: (2019)

Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4
por: Rademakers, Saskia E, et al.
Publicado: (2011)

Tumor Microenvironmental Changes Induced by the Sulfamate Carbonic Anhydrase IX Inhibitor S4 in a Laryngeal Tumor Model
por: Meijer, Tineke W. H., et al.
Publicado: (2014)

The Role of Hypoxia and the Immune System in Tumor Radioresistance
por: Span, Paul N., et al.
Publicado: (2019)

SATB1 as oncogenic driver and potential therapeutic target in head & neck squamous cell carcinoma (HNSCC)
por: Panchal, Omkar, et al.
Publicado: (2020)

Stereotactic radiotherapy boost after definite chemoradiation for non-responding locally advanced NSCLC based on early response monitoring (18)F-FDG-PET/CT
por: Meijer, Tineke W.H., et al.
Publicado: (2018)

Radiosensitization of HNSCC cells by EGFR inhibition depends on the induction of cell cycle arrests
por: Kriegs, Malte, et al.
Publicado: (2016)

Letter to the editor: Hypoxia kinetics and histology in combined radiotherapy and oxidative phosphorylation inhibition effects on antitumor immunity
por: Boreel, Daan F, et al.
Publicado: (2021)

A Novel Indication for Panobinostat as a Senolytic Drug in NSCLC and HNSCC
por: Samaraweera, Leleesha, et al.
Publicado: (2017)

ACLY (ATP Citrate Lyase) Mediates Radioresistance in Head and Neck Squamous Cell Carcinomas and is a Novel Predictive Radiotherapy Biomarker
por: Göttgens, Eva-Leonne, et al.
Publicado: (2019)

A retrospective analysis of the prognosis of prostate cancer patients with lymph node involvement on MR lymphography: who might be cured
por: Meijer, Hanneke JM, et al.
Publicado: (2013)

Parametric mapping of immunohistochemically stained tissue sections; a method to quantify the colocalization of tumor markers
por: Rademakers, Saskia E., et al.
Publicado: (2011)

Genotyping and Characterization of HPV Status, Hypoxia, and Radiosensitivity in 22 Head and Neck Cancer Cell Lines
por: Göttgens, Eva-Leonne, et al.
Publicado: (2021)

Systematic analysis of (18)F-FDG PET and metabolism, proliferation and hypoxia markers for classification of head and neck tumors
por: Hoeben, Bianca AW, et al.
Publicado: (2014)

Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF‐1α
por: Wang, Xiaoning, et al.
Publicado: (2023)

Hypoxia Mediates Differential Response to Anti-EGFR Therapy in HNSCC Cells
por: Wiechec, Emilia, et al.
Publicado: (2017)

Correction to “Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF‐1α”
Publicado: (2023)

How to Increase the Efficacy of Immunotherapy in NSCLC and HNSCC: Role of Radiation Therapy, Chemotherapy, and Other Strategies
por: Nardone, Valerio, et al.
Publicado: (2018)

Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response
por: Wennemers, Marloes, et al.
Publicado: (2011)

Constitutive or Induced HIF-2 Addiction is Involved in Resistance to Anti-EGFR Treatment and Radiation Therapy in HNSCC
por: Coliat, Pierre, et al.
Publicado: (2019)

Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response
por: Nagelkerke, Anika, et al.
Publicado: (2013)

HIF-1α and HIF-2α Differently Regulate the Radiation Sensitivity of NSCLC Cells
por: Moreno Roig, Eloy, et al.
Publicado: (2019)

Improving Breast Cancer Treatment Specificity Using Aptamers Obtained by 3D Cell-SELEX
por: Nelissen, Frank H. T., et al.
Publicado: (2021)

Expression of carbonic anhydrase IX suggests poor response to therapy in rectal cancer
por: Span, P N, et al.
Publicado: (2009)

HIF repressors under chronic hypoxia
por: Luo, Weibo, et al.
Publicado: (2016)

Hypoxia/HIF Modulates Immune Responses
por: Chen, Yuling, et al.
Publicado: (2021)

Regulation of chromatin accessibility by hypoxia and HIF
por: Batie, Michael, et al.
Publicado: (2022)

HIF-stabilizing biomaterials: from hypoxia-mimicking to hypoxia-inducing
por: Colombani, Thibault, et al.
Publicado: (2023)

Exploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish models
por: Elks, Philip M., et al.
Publicado: (2015)

Incidence and survival of HNSCC patients living with HIV compared with HIV-negative HNSCC patients
por: Haase, Katharina, et al.
Publicado: (2021)

Prognostic and predictive significance of nuclear HIF1α expression in locally advanced HNSCC patients treated with chemoradiation with or without nimotuzumab
por: Patel, Usha, et al.
Publicado: (2020)

Effect of radiochemotherapy on T2* MRI in HNSCC and its relation to FMISO PET derived hypoxia and FDG PET
por: Wiedenmann, Nicole, et al.
Publicado: (2018)

Hypoxia. The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis
por: Muz, Barbara, et al.
Publicado: (2009)

Head and neck squamous cell carcinoma cell lines have an immunomodulatory effect on macrophages independent of hypoxia and toll-like receptor 9
por: Ishizu, Tamiko, et al.
Publicado: (2021)

Hypoxia regulates RNA splicing of HIF targets
por: Hu, Cheng-Jun
Publicado: (2014)

VHL and Hypoxia Signaling: Beyond HIF in Cancer
por: Zhang, Jing, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_tfu7uhjka2hfi7letghoo7teuf