Cargando…
The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main pathological features of AD is the prese...
Autores principales: | MacLeod, Ruth, Hillert, Ellin-Kristina, Cameron, Ryan T, Baillie, George S |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Science Ltd
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137966/ https://www.ncbi.nlm.nih.gov/pubmed/28031886 http://dx.doi.org/10.4155/fso.15.9 |
Ejemplares similares
-
BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer’s Disease
por: Maia, Miguel A., et al.
Publicado: (2019) -
Computer-Aided Drug Design of β-Secretase, γ-Secretase and Anti-Tau Inhibitors for the Discovery of Novel Alzheimer’s Therapeutics
por: Mouchlis, Varnavas D., et al.
Publicado: (2020) -
γ-Secretase in Alzheimer’s disease
por: Hur, Ji-Yeun
Publicado: (2022) -
Probing Mechanisms and Therapeutic Potential of γ-Secretase in Alzheimer’s Disease
por: Wolfe, Michael S.
Publicado: (2021) -
Interplay between α-, β-, and γ-Secretases Determines Biphasic Amyloid-β Protein Level in the Presence of a γ-Secretase Inhibitor
por: Ortega, Fernando, et al.
Publicado: (2013)