Empirical Validation of a Hypothesis of the Hormetic Selective Forces Driving the Evolution of Longevity Regulation Mechanisms

Exogenously added lithocholic bile acid and some other bile acids slow down yeast chronological aging by eliciting a hormetic stress response and altering mitochondrial functionality. Unlike animals, yeast cells do not synthesize bile acids. We therefore hypothesized that bile acids released into an...

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Detalles Bibliográficos
Autores principales: Gomez-Perez, Alejandra, Kyryakov, Pavlo, Burstein, Michelle T., Asbah, Nimara, Noohi, Forough, Iouk, Tania, Titorenko, Vladimir I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138192/
https://www.ncbi.nlm.nih.gov/pubmed/27999589
http://dx.doi.org/10.3389/fgene.2016.00216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138192/
https://www.ncbi.nlm.nih.gov/pubmed/27999589
http://dx.doi.org/10.3389/fgene.2016.00216

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