Cargando…
Upward movement of IS4 and IIIS4 is a rate-limiting stage in Ca(v)1.2 activation
In order to specify the role of individual S4 segments in Ca(V)1.2 gating, charged residues of segments IS4-IVS4 were replaced by glutamine and the corresponding effects on activation/deactivation of calcium channel currents were analysed. Almost all replacements of charges in IS4 and IIIS4 decrease...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138263/ https://www.ncbi.nlm.nih.gov/pubmed/27796578 http://dx.doi.org/10.1007/s00424-016-1895-5 |