Cargando…

Upward movement of IS4 and IIIS4 is a rate-limiting stage in Ca(v)1.2 activation

In order to specify the role of individual S4 segments in Ca(V)1.2 gating, charged residues of segments IS4-IVS4 were replaced by glutamine and the corresponding effects on activation/deactivation of calcium channel currents were analysed. Almost all replacements of charges in IS4 and IIIS4 decrease...

Descripción completa

Detalles Bibliográficos
Autores principales:	Beyl, Stanislav, Hohaus, Annette, Andranovits, Stanislav, Timin, Eugen, Hering, Steffen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2016
Materias:	Ion Channels, Receptors and Transporters
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138263/ https://www.ncbi.nlm.nih.gov/pubmed/27796578 http://dx.doi.org/10.1007/s00424-016-1895-5

Ejemplares similares

Key role of segment IS4 in Cav1.2 inactivation: link between activation and inactivation
por: Andranovits, Stanislav, et al.
Publicado: (2017)

Physicochemical properties of pore residues predict activation gating of Ca(V)1.2: A correlation mutation analysis
por: Beyl, Stanislav, et al.
Publicado: (2010)

Methods for quantification of pore–voltage sensor interaction in Ca(V)1.2
por: Beyl, S., et al.
Publicado: (2013)

Channelopathies in Ca(v)1.1, Ca(v)1.3, and Ca(v)1.4 voltage-gated L-type Ca(2+) channels
por: Striessnig, Jörg, et al.
Publicado: (2010)

Beyond Ca(2+) signalling: the role of TRPV3 in the transport of NH(4)(+)
por: Liebe, Hendrik, et al.
Publicado: (2021)

Effects of butyrate(−) on ruminal Ca(2+) transport: evidence for the involvement of apically expressed TRPV3 and TRPV4 channels
por: Liebe, Franziska, et al.
Publicado: (2022)

TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons
por: Menigoz, Aurélie, et al.
Publicado: (2015)

Activation of the Ca(2+)-sensing receptors increases currents through inward rectifier K(+) channels via activation of phosphatidylinositol 4-kinase
por: Liu, Chung-Hung, et al.
Publicado: (2016)

Enhanced Ca(2+) influx through cardiac L-type Ca(2+) channels maintains the systolic Ca(2+) transient in early cardiac atrophy induced by mechanical unloading
por: Schwoerer, A. P., et al.
Publicado: (2013)

Mitochondrial Ca(2+) uniporter (MCU)-dependent and MCU-independent Ca(2+) channels coexist in the inner mitochondrial membrane
por: Bondarenko, Alexander I., et al.
Publicado: (2013)

Synergistic interplay of Gβγ and phosphatidylinositol 4,5-bisphosphate dictates Kv7.4 channel activity
por: Povstyan, Oleksandr V., et al.
Publicado: (2016)

Na(+)/Ca(2+) exchangers and Orai channels jointly refill endoplasmic reticulum (ER) Ca(2+) via ER nanojunctions in vascular endothelial cells
por: Di Giuro, Cristiana M. L., et al.
Publicado: (2017)

Characterization of distinct single-channel properties of Ca(2+) inward currents in mitochondria
por: Bondarenko, Alexander I., et al.
Publicado: (2013)

Calpain-3-mediated regulation of the Na(+)-Ca(2+) exchanger isoform 3
por: Michel, Lauriane Y. M., et al.
Publicado: (2015)

Structural basis of PI(4,5)P(2)-dependent regulation of GluA1 by phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (PIP5K2A)
por: Seebohm, Guiscard, et al.
Publicado: (2014)

TRPV4 and TRPM8 as putative targets for chronic low back pain alleviation
por: Fozzato, Stefania, et al.
Publicado: (2020)

The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores
por: Zong, Xiangang, et al.
Publicado: (2009)

Anoctamin 6 differs from VRAC and VSOAC but is involved in apoptosis and supports volume regulation in the presence of Ca(2+)
por: Juul, C. A., et al.
Publicado: (2014)

UCP2 modulates single-channel properties of a MCU-dependent Ca(2+) inward current in mitochondria
por: Bondarenko, Alexander I., et al.
Publicado: (2015)

Functional expression of mitochondrial K(Ca)3.1 channels in non-small cell lung cancer cells
por: Bulk, Etmar, et al.
Publicado: (2022)

Hydrogen peroxide induces vasorelaxation by enhancing 4-aminopyridine-sensitive Kv currents through S-glutathionylation
por: Park, Sang Woong, et al.
Publicado: (2014)

Disease-associated HCN4 V759I variant is not sufficient to impair cardiac pacemaking
por: Erlenhardt, Nadine, et al.
Publicado: (2020)

TRPM4-specific blocking antibody attenuates reperfusion injury in a rat model of stroke
por: Chen, Bo, et al.
Publicado: (2019)

RBP2 stabilizes slow Cav1.3 Ca(2+) channel inactivation properties of cochlear inner hair cells
por: Ortner, Nadine J., et al.
Publicado: (2019)

Endothelial-dependent dilation following chronic hypoxia involves TRPV4-mediated activation of endothelial BK channels
por: Naik, Jay S., et al.
Publicado: (2018)

Soluble αKlotho downregulates Orai1-mediated store-operated Ca(2+) entry via PI3K-dependent signaling
por: Kim, Ji-Hee, et al.
Publicado: (2021)

Effects of syntaxins 2, 3, and 4 on rat and human epithelial sodium channel (ENaC) in Xenopus laevis oocytes
por: Rauh, Robert, et al.
Publicado: (2020)

Ligand sensitivity of type-1 inositol 1,4,5-trisphosphate receptor is enhanced by the D2594K mutation
por: Tambeaux, Allison, et al.
Publicado: (2023)

TMEM16A knockdown abrogates two different Ca(2+)-activated Cl(−) currents and contractility of smooth muscle in rat mesenteric small arteries
por: Dam, Vibeke Secher, et al.
Publicado: (2013)

Antiarrhythmic effect of the Ca(2+)-activated K(+) (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation
por: Kirchhoff, Jeppe Egedal, et al.
Publicado: (2016)

Neuronal nitric oxide synthase regulation of calcium cycling in ventricular cardiomyocytes is independent of Ca(v)1.2 channel modulation under basal conditions
por: Ebner, Janine, et al.
Publicado: (2019)

Two firing modes and well-resolved Na(+), K(+), and Ca(2+) currents at the cell-microelectrode junction of spontaneously active rat chromaffin cell on MEAs
por: Marcantoni, Andrea, et al.
Publicado: (2022)

Sex difference in kidney electrolyte transport III: Impact of low K intake on thiazide-sensitive cation excretion in male and female mice
por: Xu, Shuhua, et al.
Publicado: (2021)

CK2 is a key regulator of SLC4A2-mediated Cl(−)/HCO(3)(−) exchange in human airway epithelia
por: Ibrahim, Salam H., et al.
Publicado: (2017)

KCNE1 does not shift TMEM16A from a Ca(2+) dependent to a voltage dependent Cl(-) channel and is not expressed in renal proximal tubule
por: Talbi, Khaoula, et al.
Publicado: (2023)

Ubiquitin-specific protease USP2-45 acts as a molecular switch to promote α(2)δ-1-induced downregulation of Ca(v)1.2 channels
por: Rougier, Jean-Sebastien, et al.
Publicado: (2014)

A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P(2)
por: Telezhkin, Vsevolod, et al.
Publicado: (2013)

Determinants of the voltage dependence of G protein modulation within calcium channel β subunits
por: Dresviannikov, Andriy V., et al.
Publicado: (2008)

Cleavage of endogenous γENaC and elevated abundance of αENaC are associated with increased Na(+) transport in response to apical fluid volume expansion in human H441 airway epithelial cells
por: Tan, Chong D., et al.
Publicado: (2011)

TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP
por: Mandadi, Sravan, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_h7arrjfuoeupk2kf471l06arvm