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Upward movement of IS4 and IIIS4 is a rate-limiting stage in Ca(v)1.2 activation

In order to specify the role of individual S4 segments in Ca(V)1.2 gating, charged residues of segments IS4-IVS4 were replaced by glutamine and the corresponding effects on activation/deactivation of calcium channel currents were analysed. Almost all replacements of charges in IS4 and IIIS4 decrease...

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Detalles Bibliográficos
Autores principales:	Beyl, Stanislav, Hohaus, Annette, Andranovits, Stanislav, Timin, Eugen, Hering, Steffen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2016
Materias:	Ion Channels, Receptors and Transporters
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138263/ https://www.ncbi.nlm.nih.gov/pubmed/27796578 http://dx.doi.org/10.1007/s00424-016-1895-5

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