Regulation of gap junction conductance by calcineurin through Cx43 phosphorylation: implications for action potential conduction

Cardiac arrhythmias are associated with raised intracellular [Ca(2+)] and slowed action potential conduction caused by reduced gap junction (GJ) electrical conductance (Gj). Ventricular GJs are composed of connexin proteins (Cx43), with Gj determined by Cx43 phosphorylation status. Connexin phosphor...

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Detalles Bibliográficos
Autores principales: Jabr, Rita I, Hatch, Fiona S, Salvage, Samantha C, Orlowski, Alejandro, Lampe, Paul D, Fry, Christopher H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Molecular and Cellular Mechanisms of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138272/
https://www.ncbi.nlm.nih.gov/pubmed/27757582
http://dx.doi.org/10.1007/s00424-016-1885-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138272/
https://www.ncbi.nlm.nih.gov/pubmed/27757582
http://dx.doi.org/10.1007/s00424-016-1885-7

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