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The urgent need to recover MHC class I in cancers for effective immunotherapy

Immune escape strategies aimed to avoid T-cell recognition, including the loss of tumor MHC class I expression, are commonly found in malignant cells. Tumor immune escape has proven to have a negative effect on the clinical outcome of cancer immunotherapy, including treatment with antibodies blockin...

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Detalles Bibliográficos
Autores principales: Garrido, Federico, Aptsiauri, Natalia, Doorduijn, Elien M, Garcia Lora, Angel M, van Hall, Thorbald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138279/
https://www.ncbi.nlm.nih.gov/pubmed/26796069
http://dx.doi.org/10.1016/j.coi.2015.12.007